Progress in Genetics and Genomics of Nonhuman Primates

摘要

The papers in this issue of the ILAR Journal discuss the current understanding of the genetics and genomics of apes (particularly the chimpanzee), and old world monkeys, such as macaques, baboons, and vervets. These species provide highly relevant models for many aspects of human physiology, behavior, and disease. They also enhance the understanding of evolutionary biology. These animals have been used widely for many aspects of discovery science. As directly related to translational research, monkeys, in particular, are used extensively to test the efficacy of vaccines, therapies for human disease, and for examining the toxicity of drug candidates. Classic examples of the importance of nonhuman primates (NHPs) used for translational research are the development of vaccines for polio (Sabin 1985; Salk and Salk 1984), hepatitis A (Purcell and Emerson 2001), and hepatitis B (Chisari 2000).