New Diclofenac Derivatives as Anti-Microbial, Anti-Inflammatory Agents: Design, Synthesis, Biological Screening, and Molecular Docking Study

摘要

Diclofenac is considered one of the best drugs used as anti-inflammatory agent, so in the present work new diclofenac derivatives containing bioactive moieties, such as triazole, oxadiazole, and thiadiazol, were synthesized. The structures of the new compounds were established based on spectral and elemental analysis. The new synthesized compounds were tested against anti-inflammatory agents and exhibited high activity as expected. The binding position of new diclofenac derivatives toward Cox-1 and Cox-2 enzymes was proved by molecular docking. Also, some of the new compounds were tested against bacteria and displayed high activity.