Platelet-derived growth factor receptors (PDGFRs) fusion genes involvement in hematological malignancies

Appiah-Kubi Kwaku; Lan Ting; Wang Ying; Qian Hai; Wu Min; Yao Xiaoyuan; Wu Yan; Chen Yongchang

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Platelet-derived growth factor receptors (PDGFRs) fusion genes involvement in hematological malignancies

机译：血小板衍生的生长因子受体（PDGFRS）融合基因受累血液恶性肿瘤

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Purpose: To investigate oncogenic platelet-derived growth factor receptor(PDGFR) fusion genes involvement in hematological malignancies, the advances in the PDGFR fusion genes diagnosis and development of PDGFR fusions inhibitors.

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来源
《Critical reviews in oncology/hematology》 |2017年第1期|共15页
作者
Appiah-Kubi Kwaku; Lan Ting; Wang Ying; Qian Hai; Wu Min; Yao Xiaoyuan; Wu Yan; Chen Yongchang;
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作者单位

Jiangsu Univ Sch Med Dept Physiol 301 Xuefu Rd Zhenjiang 212013 Jiangsu Peoples R China;

Jiangsu Univ Sch Med Dept Physiol 301 Xuefu Rd Zhenjiang 212013 Jiangsu Peoples R China;

Jiangsu Univ Sch Med Dept Physiol 301 Xuefu Rd Zhenjiang 212013 Jiangsu Peoples R China;

Jiangsu Univ Sch Med Dept Physiol 301 Xuefu Rd Zhenjiang 212013 Jiangsu Peoples R China;

Jiangsu Univ Sch Med Dept Physiol 301 Xuefu Rd Zhenjiang 212013 Jiangsu Peoples R China;

Changchun Med Coll Basic Med Dept Changchun 130013 Jilin Peoples R China;

Jiangsu Univ Sch Med Dept Physiol 301 Xuefu Rd Zhenjiang 212013 Jiangsu Peoples R China;

Jiangsu Univ Sch Med Dept Physiol 301 Xuefu Rd Zhenjiang 212013 Jiangsu Peoples R China;

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原文格式 PDF
正文语种 eng
中图分类肿瘤学;
关键词
PDGFRs; Fusion genes; Myeloid neoplasm; Lymphoid neoplasm; Chromosomal translocation;

机译：PDGFRS;融合基因;骨髓肿瘤;淋巴肿瘤;染色体易位;

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1. Expression and functional characterization of platelet-derived growth factor receptor-like gene [J] . 无世界胃肠病学杂志：英文版 . 2010,第012期
2. Effects of ribozyme targeting platelet-derived growth factor receptor β subunit gene on the proliferation and apoptosis of hepatic stellate cells in vitro [J] . CHEN Yue-xiang, LU Cui-hua, XIE Wei-fen, 中华医学杂志（英文版） . 2005,第012期
3. Reversion of malignancy in human gastric cancer MKN—45 cells through the transfection of transforming growth factor—β type Ⅱ receptor gene [J] . SUNHONG, WEIKANGSHI, 等细胞研究：英文版 . 1996,第002期
4. Stimulation of Platelet-derived Growth Factor Receptor β (PDGFRβ) Activates ADAM17 and Promotes Metalloproteinase-dependent Cross-talk between the PDGFRβ and Epidermal Growth Factor Receptor (EGFR) Signaling Pathways [J] . Karen Mendelson, Steven Swendeman, Paul Saftig, The Journal of biological chemistry . 2010,第32期

机译：血小板衍生的生长因子受体β（PDGFRβ）的刺激激活ADAM17并促进PDGFRβ和表皮生长因子受体（EGFR）信号传导途径之间的金属蛋白酶依赖性串扰
5. 767 POSTER Targeting the tyrosine kinase platelet-derived growth factor beta-receptor (PDGFR-b) in advanced gastrointestinal malignancies-a phase I dose escalation study with imatinib in combination with 5-fluorouracil (5-FU) based chemotherapy [J] . European Journal of Cancer Supplements . 2005,第2期

机译：767 POSTER在晚期胃肠道恶性肿瘤中靶向酪氨酸激酶血小板衍生的生长因子β受体（PDGFR-b）-伊马替尼联合基于5-氟尿嘧啶（5-FU）的化疗的I期剂量递增研究
6. Platelet-derived growth factor receptor/platelet-derived growth factor (PDGFR/PDGF) system is a prognostic and treatment response biomarker with multifarious therapeutic targets in cancers [J] . Appiah-Kubi Kwaku, Wang Ying, Qian Hai, Tumour biology : . 2016,第8期

机译：血小板衍生生长因子受体/血小板衍生生长因子（PDGFR / PDGF）系统是具有多种治疗靶点的癌症预后和治疗反应生物标志物
7. IS PLATELET-DERIVED GROWTH FACTOR RECEPTOR-BETA A PLAYER IN CANINE HEMANGIOSARCOMA? [C] . Stuart Helfand, Kevin Marley, Erin Dickerson, Annual Conference of the Veterinary Cancer Society . 2009

机译：血小板衍生的生长因子受体-β在犬血管核中的球员吗？
8. Platelet-derived growth factor receptor beta and platelet-derived growth factor B-chain in vascular reaction to injury and angiogenesis. [D] . Buetow, Bernard Steven. 2003

机译：血小板源性生长因子受体β和血小板源性生长因子B链对损伤和血管生成的血管反应。
9. Stimulation of Platelet-derived Growth Factor Receptor β (PDGFRβ) Activates ADAM17 and Promotes Metalloproteinase-dependent Cross-talk between the PDGFRβ and Epidermal Growth Factor Receptor (EGFR) Signaling Pathways [O] . Karen Mendelson, Steven Swendeman, Paul Saftig, 2010

机译：刺激血小板衍生的生长因子受体β（PDGFRβ）激活ADAM17并促进PDGFRβ与表皮生长因子受体（EGFR）信号通路之间的金属蛋白酶依赖性串扰
10. Stimulation of Platelet-derived Growth Factor Receptor β (PDGFRβ) Activates ADAM17 and Promotes Metalloproteinase-dependent Cross-talk between the PDGFRβ and Epidermal Growth Factor Receptor (EGFR) Signaling Pathways* [O] . Mendelson, Karen, Swendeman, Steven, Saftig, Paul, 2010

机译：刺激血小板衍生的生长因子受体β（PDGFRβ）激活ADAM17并促进PDGFRβ与表皮生长因子受体（EGFR）信号通路之间的金属蛋白酶依赖性串扰*
11. Studies on Platelet-Derived Growth Factor Beta-Receptor and Hepatocyte GrowthFactor Receptor c-met in Paracrine Interactions in Human Breast Cancer [R] . Elliot, B. E. 1995

机译：人乳腺癌旁分泌相互作用中血小板衍生生长因子β受体和肝细胞生长因子受体c-met的研究

Platelet-derived growth factor receptors (PDGFRs) fusion genes involvement in hematological malignancies

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