Non-C_2-Symmetrie,Chirally Economical,and Readily Tunable Linked-binols:Design and Application in a Direct Catalytic Asymmetric Mannich-Type Reaction

摘要

Asymmetric catalysis employing chiral metal complexes is one of the most general and flexible methods in asymmetric synthesis.'1' In the development of asymmetric metal catalysts for highly enantioselective and reactive reactions,the design of chiral ligands for the metal center is of key importance:the activity and selectivity of the metal centers can be tuned by chiral ligands.A delicate balance between the steric and electronic properties of the catalyst determines the reaction efficiency.Thus,a chiral ligand with a readily tuneable framework is desirable.