High-Affinity MultIValent DNA Binding by Using Low-Molecular-Weight Dendrons

摘要

High-affinity binding between nanoscale objects is an essential prerequisite for "bottom-up" fabrication.In recent years,interest has focused on the use of dendritic macro-molecules as supramolecular nanoscale building blocks.The branched superstructure of dendrons and dendrimers offers specific advantages,for example,enhancement of weak binding by using multIValent arrays of recognition units on the dendritic surface.This multIValency principle,in which organized arrays amplify the strength of a weak binding process,such as the binding of saccharides to proteins on cell surfaces,is now well established.