Enantioselective Diels-Alder Approach to Angucyclinones from (S)-2-(p-ToIylsulfinyl)-1,4-naphthoquinone and Substituted Racemic Vinylcyclohexenes

摘要

Angucyclines are a large group of naturally occurring quinones of microbial origin that display a broad range of biological activities. This family of antibiotics shares a henz[a]anthracene framework of deaiketide origin, as well as a methyl group at C3 and an oxygen functionality at C1. The main structural differences among the members are found in the aromatic or hydroaromatic nature of the A and/or B rings. Some examples of angucyclinone antibiotics are (+)-emycin A. SF 2315A, and SF 2315B.