Ultra-rapid Synthesis of ~(15)O-Labeled 2-Deoxy-D-glucose for Positron Emission Tomography(PET)

摘要

Positron emission tomography(PET)has gained importance in clinical diagnosis and in modern medicinal chemistry.In the former application,~(18)F-labeled deoxyglucose([~(18)F]FDG)is widely used for the analysis of glucose metabolism in vivo and in the latter,PET is accelerating the pace of drug development.'Whereas efforts to develop PET tracer molecules has fallen largely in the area of ~(18)F labeling,development of a synthetic methodology suitable for more ubiquitous and natural elements is necessary,particularly for bioorganic and medicinal studies.