General Catalysts for the Suzuki-Miyaura and Sonogashira Coupling Reactions of Aryl Chlorides and for the Coupling of Challenging Substrate Combinations in Water

摘要

Metal-catalyzed cross-coupling methodology to form carbon-carbon bonds has inarguably advanced organic synthesis.The Suzuki-Miyaura coupling is one of the preeminent methods for formation of carbon-carbon bonds and has been used in numerous synthetic ventures.We recently reported a new catalyst system that manifested high activity paired with extremely broad scope.