Novel Genetically Engineered Tetracenomycins

摘要

Chemically untreatable diseases as well as increasing [lumbers of bacteria, viruses, parasites, and eaneer cells resistant to chemotherapy demand innovative eoneepls to find new mole-cules, whieh might serve as lead struelures for pharmaceutically useful drugs. Natural produets have proven to be a primary basis lor novel bioaelive molecules. Sinee the pioneering experiments of Hopwood et al. in 1485, genelieally engineered hybrid microorganisms with niodilled genes have also been diseussed as a possible source of new natural produets.