A General Sultone Route to the Pamamycin Macrodiolides-Total Synthesis of Pamamycin-621A and Pamamycin-635B

摘要

The pamamycins (1) are a class of 16-membered macrodiolide homologues that have been isolated from various Streptomy-ces species (Table 1).Besides displaying pronounced autoregulatory,anionophoric,and antifungal activities,several members of this family have been shown to be highly active against Gram-positive bacteria including multiple antibiotic-resistant strains of Mycobacterium tuberculosis.