Real-Time Observation of Ionization-Induced Hydrophobic ->Hydrophilic Switching

摘要

Noncovalent interactions are responsible for fundamental properties of complex molecular systems that occur in our macroscopic world.In particular,the structure,dynamics,and function of supramolecular systems such as DNA are entirely governed by noncovalent interactions.Most of our understanding of noncovalent forces has come from quantum chemical calculations.For example,a sophisticated ab ini-tio treatment of intermolecular interactions in DNA base pairs has elucidated the competition between specific hydrogen-bonding and aromatic pi-stacking interactions.For the total stabilization energy of DNA,the stacking contribution was estimated to be about two-thirds of that of the hydrogen-bond contributions,substantially higher than it was previously thought.