Total Synthesis of Natural Myriaporones

摘要

Myriaporones 1–4 (1–4, respectively) are a new class of cytotoxic marine polyketide-derived compounds that exhibit significant cytotoxic activity against L1210 cells. These compounds 1–4 were isolated by Rinehart and co-workers in 1995 from the bryozoan Myriapora truncata.[1] The most active constituents, 3 and 4, were isolated as a mixture of cyclic and open-chain isomers. The myriaporones are structurally related to the C10–C23 region of the macrocycles tedanolide (5)[2] and deoxytedanolide (6),[3,4] although the configuration at C5 of 1 and 2 and at C5 and C6 of 3 and 4 were not unequivocally determined.