Recent Developments in the Catalytic Asymmetric Cyanation of Ketimines

摘要

In several research groups a,a-dialky-latedamino acids (α,α-DAAs) are currently a subject of intense investigation from both biological and synthesis standpoints. Several desirable features of a,a-DAAs have attracted the attention of the pharmaceutical industry. Their incorporation into peptides and proteins might affect the secondary or tertiary structure and confer unusual and interesting biological properties. The quaternary center in an α,α-DAA preserves its stereochemical integrity and often imparts increased metabolic stability to the peptide. Also, many α,α-DAAs are powerful enzyme inhibitors.