A Tandem Semipinacol Rearrangement/Alkylation of -Epoxy Alcohols: An Efficient and Stereoselective Approach to Multifunctional 1,3-Diols

摘要

Multifunctional 1,3-diols with an allyl or a propargyl group and three consecutive stereocenters, two of which are quaternary carbon atoms, form a class of important building blocks that is required for the synthesis of many biologically significant molecules, such as sieboldine A, furaquinocins, and ingenol. The stereoselective construction of the quaternary carbon centers, in particular, has received considerable attention.