Enzyme Microarrays:On-Chip Determination of Inhibition Constants Based on Affinity-Label Detection of Enzymatic Activity

摘要

The completion of the human genome's deciphering is opening previously unforeseeable opportunities.This major step towards the understanding and control of living bodies lays a fertile ground for proteomic science and,in particular,for the identification of novel enzymatic therapeutic targets.The understanding of the biochemical complexity is paralleled,in the chemical sciences,by an ever-increasing ability to generate large numbers of vastly diverse chemical structures.