Copper(II)-Catalyzed Highly Enantioselective Addition of Enamides to Imines: The Use of Enamides as Nucleophiles in Asymmetric Catalysis

摘要

Enamides are potentially useful and atom-economical nucleophiles that contain amide or carbamate moieties after nucleophilic additions. While enamides can be easily prepared, handled, and stored at room temperature, their use in organic synthesis is limited.[2] To the best of our knowledge, there have been no reports of using enamides as nucleophiles in asymmetric catalysis.We describe here the first example of the enantioselective addition of enamides to imines using a chiral copper catalyst.