Direct Catalytic Enantioselective alpha-aminoxylation of Ketones:A Stereoselective Synthesis of alpha-Hydroxy and alpha,alpha'-Dihydroxy Ketones

摘要

One of the ultimate goals and challenges in chemistry is to develop catalytic stereoselective transformations for the creation of optically active molecules from simple and easily available starting materials.Optically active alpha-hydroxy carbonyl moieties are commonly found in numerous important natural products.This has led to extensive research to find new diastereoselective and enantioselective routes for their syntheses.