Total Synthesis of Thiostrepton,Part 2:Construction of the Quinaldic Acid Macrocycle and Final Stages of the Synthesis

摘要

In the preceding Communication in this issue we described the construction of the thiazoline-containing macrocycle 2 as an advanced intermediate toward the total synthesis of thiostrepton(1).Herein we report the construction of suitable dipeptide(8,Scheme 1)and quinaldic acid(22,Scheme 2)fragments,their union with 2,and the final stages of the total synthesis of 1.