Mixed Helices-A General Folding Pattern in Homologous Peptides?

摘要

Oligomers composed entirely of unnatural monomers that form characteristic secondary structures have attracted considerable attention in the last years. The motivation for work in this area ranges from gaining a better understanding of the structure and function of biomolecules and imitating them to developing polymers with novel properties. Considerable stimulation of research on these foldamers came from the investigation of β-peptides. Numerous secondary structures were found in these p-peptides as well as in homologous γ-and δ-peptides.