Concise Syntheses of Meridianins by Carbonylative Alkynylation and a Four-Component Pyrimidine Synthesis

摘要

Pyrimidines constitute an important class of heterocycles, and many of the 2,4-substituted pyrimidines have been recognized to be pharmaceutically highly active.Particular attention has focused on meridianins A-G (indole alkaloids with a 2-aminopyrimidyl substituent which were recently isolated from the Aplidium meridianum,an ascidian collected in the South Atlantic;Scheme I),since they inhibit numerous protein kinases in a low micromolar range.