Mechanism of the Ligand-Free Cu~I-Catalyzed Azide-Alkyne Cycloaddition Reaction

摘要

The 1,3-dipolar Cycloaddition of azides and alkynes is an effective way to make connections between structures that bear a wide variety of functional groups.The process is strongly favored in thermodynamic terms,yet both azide and alkyne units are highly selective in their reactivity;they are inert to most chemical functionalities and are stable in wide ranges of solvents,temperatures,and pH values.