Organocatalytic Asymmetric alpha-Halogenation of 1,3-Dicarbonyl Compounds

摘要

The enantioselective construction of carbon-halogen stereogenicity belongs to the topical area of current asymmetric catalysis by virtue of the fact that halogen atoms attached to a chiral stereocenter can serve as a linchpin for further stereospecific manipulations.Moreover,optically active halogen-containing compounds are increasingly important targets in drug discovery and material sciences.Despite this,different efficient catalytic asymmetric halogenation strategies have been developed only in the last few years.