Membrane-Mimetic Nanocarriers Formed by a Dipalmitoylated Cell-Penetrating Peptide

摘要

Molecular and supramolecular drug-delivery systems have attracted great attention as pharmaceutical formulations for the administration of otherwise only poorly soluble,rapidly degradable,or even toxic molecules.Within the multitude of colloidal vehicles developed to date,micelles belong to the most useful tools for the delivery of hydrophobic compounds.However,some serious disadvantages of micellar carriers remain,among which the problem that some normally membrane-located biomolecular devices like vector peptides lose their native conformation and are severely compromised in their activity when removed from the lipid bilayer.Here we introduce a dipalmitoylated cell-penetrating peptide that is superior to previously described biofunctional colloids in its ability to incorporate large amounts of lipid in mixed micelles.Hence this peptide constitutes a potent lead for the intracellular delivery of hydrophobic drugs using bilayer-mimetic nanocarriers.