The Design and Evaluation of Heparin-Binding Foldamers

摘要

Foldamers,nonbiological oligomers with well-defined secondary or tertiary structures,provide novel templates for the design of biologically active molecules that compete for a variely to protein-protein and potein-membrane interactions.Their semirigid structures and their adjustable lengths mean that they provide excellent starting points for the elaboration of protein mimics that might be difficult to design based on small-molecule scaffolds.