Coupled Hydrogen-Bonding Networks in Polyhydroxylated Peptides

摘要

The active sites of proteins contain networks of hydrogen bonds which are functionally coupled to perform the enzyme function.The side chains of short peptides cannot align in comparable microenvironments because they are too flexible to form more than transient hydrogen bonds.Dipeptides which are highly decorated with ring-constrained hydrogen-bond donors and acceptors can be assembled to oligocyclic peptidomimetics which are then confined to only a few modes of flexibility.