Targeted Enzyme-Responsive Drug Carriers: Studies on the Delivery of a Combination of Drugs

摘要

A wide variety of new synthetic compounds have been screened for chemotherapeutic applications. However, many drug candidates exhibit poor membrane permeability and/or severe side effects caused by their lack of selectivity. These problems can often be overcome by using highly specific chemotherapeutic agents. On the other hand, considerable efforts have been devoted to the creation of delivery systems targeting infected cells (or malignant tumors); these systems improve membrane permeability, therapeutic efficacy, and selectivity.