Enantioselective Allylation of Aromatic Amines after In Situ Generation of an Activated Cyclometalated Iridium Catalyst

摘要

Aromatic amines with a stereocenter a to the nitrogen atom are important structural motifs in a number of biologically active compounds.Many of approaches to such structures have been investigated,but each method has limitations.Thus,a highly enantioselective procedure to prepare optically active aromatic amines would be valuable,and an enantioselective route to N-aryl allylic amines would be particularly useful because of the dual functionality in these compounds.