Oxonitriles: Multicomponent Grignard Addition-Alkylations

摘要

Efficiently installing high molecular complexity is a fundamental pursuit in organic synthesis. Several excellent strategies have emerged for installing multiple bonds in a single synthetic operation; bidirectional synthesis, domino reactions, biomimetic cascades, and multicomponent reactions. Each strategy exhibits complementary advantages, with multicomponent reactions benefiting from an inherent convergence that fulfills the synthetic criteria of assembling complex targets from fragments of similar size.