Self-Assembly of a Cavitand-Based Capsule by Dynamic Boronic Ester Formation

摘要

Carcerands and hemicarcerands, in which two calix[4]resor-cinarene cavitands are held together by four covalent linkages, have been developed by Cram and others. They have attracted considerable attention from the viewpoint of stabilization of reactive intermediates and as microvesicles for drug delivery by the confinement of guest molecules inside the capsules away from bulk phases.Error correction through thermodynamic equilibration, minimization of synthetic effort by use of modular subunits, and control of assembly processes through subunit design are characteristics of supramolecular approaches to self-assembly.