Heterodimerization of Olefins: A Highly Promising Strategy for the Selective Synthesis of Functionalized Alkenes

摘要

Enamides, enol esters, alpha,beta-unsaturated carbonyl compounds, vinyl halides, vinyl boronic acids-these are just a few examples of alkenes that carry an additional functionality directly attached to the double bond. Such substructures are found both in pharmaceutically active compounds (for example, enamides in the active antitumor agents lobata-mide and salicylihalamide or 2-alkylidenetetrahydrofur-ans in macrotetrolide antibiotics) and in functional materials such as polyvinylpyrrolidone derivates. In addition, they are versatile synthetic intermediates for Diels-Alder reactions, polymerizations, cycloadditions, cross-coupling reactions, Heck reactions, enantioselective additions, and asymmetric hydrogenations.