Highly Efficient Synthesis of Tricyclic Amines by a Cyclization/Cycloaddition Cascade:Total Syntheses of Aspidospermine,Aspidospermidine,and Quebrachamine

摘要

Reactions that occur in a single pot to form more than two chemical bonds or new ring systems provide the means to prepare complex compounds in a highly efficient manner.Multicomponent reactions or multiple-bond formations through cascade processes can be exploited for such chemistry.For example,a powerful method to access bicyclic compounds involves the formation of a 1,3-dipole followed by intramolecular cycloaddition.