Catalytic Metathesis of Simple Secondary Amides

摘要

Reactions that interconvert strong covalent bonds,generally known as dynamic covalent chemistry (DCC),offer a powerful approach for the thermodynamically controlled synthesis of organic molecules with interesting structures and/or properties.DCC involving esters,thioesters,imines,and disulfides,among other functional groups,has provided access to interesting new molecules.Such efforts to date have focused on bonds that were previously known to be readily exchangeable.Extension of the DCC approach to other types of functional groups will require advances in organic reactivity and catalysis.