Alkylation of Aryl N-(2-Pyridylsulfonyl)aldimines with Organozinc Hal ides:Conciliation of Reactivity and Chemoselectivity

摘要

The direct addition of organometallic reagents to imines is a very convergent route to alpha-branched primary and secondary amines.Consequently,a number of synthetically useful addition reactions for the formation of carbon-carbon bonds have been developed with organolithium,Grignard,dialkyl zinc,alkenyl zirconium,aryl tin,aryl titanium,and aryl boron reagents as nucleophiles,including some very efficient catalytic enantioselective procedures.