Peptide Microarray for High-Throughput Determination of Phosphatase Specificity and Biology

摘要

Reversible phosphorylation of proteins(a critical posttransla-tional event catalyzed by kinases and phosphatases)occurs in >20% of human proteins.Although kinases have been studied extensively,knowledge about the biological characterization of phosphatases,for example,their cellular partners and substrate specificities,is limited.