The Catalytic Asymmetric Strecker Reaction:Ketimines Continue to Join the Fold

摘要

I he operational simplicity,relative atom economy,and ready availability of starting materials make the Strecker synthesis a cornerstone technology for the preparation of both natural and unnatural a-amino acids today-over 150 years after Adolf Strecker first reported the synthesis of alanine by the hydrolysis of the adduct formed from the addition of ammonia and hydrogen cyanide to acetaldehyde.The addition of HCN to a preformed imine in general is often referred to as the Strecker reaction.