Palladium-Catalyzed Tandem Heck Reaction/C-H Fimctionalization-Preparation of Spiro-Indane-Oxindoles

摘要

The oxindole framework is a motif common to natural products and pharmaceutically active compounds.'21 In particular,3,3-disubstituted oxindoles have shown promising biological activity.Considerable efforts have been dedicated to developing new methods for the preparation of these pharmacaphores,especially spiro-oxindoles:functionaliza-tion of heterocycles,variations of the Stolle reaction,epoxide rearrangement,Lewis acid promoted cyclization,Pummerer rearrangement,and various palladium-catalyzed methodologies.