Total Synthesis of Callystatin A by Titanium-Mediated Reductive Alkyne-Alkyne Cross-Coupling

摘要

Members of the leptomcyin family of natural products possess potent cell-cycle-regulating properties,in addition to apop-totic,antifungal,and antiviral activities(Scheme 1).The origin of these properties is thought to derive from the known propensity of these natural products to modulate the function of the exportin chromosomal region maintenance 1(CRM1)and to inhibit nuclear export.