Cyclic Peptides Bearing a Side-Chain Tail:A Tool to Model the Structure and Reactivity of Protein Zinc Sites

摘要

A recent bioinformatics study has evaluated to about 1000(or ca.3% of the total protein number)the number of human proteins possessing a tetracysteinate zinc site.These sites were initially presumed to have a structural role because they were associated to zinc finger proteins,where they fold the protein chain in a conformation suitable for its binding to DNA.They were later found in several proteins and enzymes involved in demethylation processes,such as the DNA repair protein Ada and various transferases.