Enantioselective Insertion of Metal Carbenes into N-H Bonds:A Potentially Versatile Route to Chiral Amine Derivatives

摘要

The formation of carbon-heteroatom bonds is one of the fundamental transformations of organic chemistry.One potentially powerful method is the insertion of metal carbenes,readily derived by transition-metal-catalyzed reactions of diazo compounds 1,into X-H bonds (Scheme 1).