Hydrogen Peroxide Triggered Prochelator Activation,Subsequent Metal Chelation,and Attenuation of the Fenton Reaction

摘要

Iron and copper are redox-active metals essential for life.Hydrogen peroxide(H2O2)is also essential for cellular activities and has recently been identified as a second messenger.However,iron,copper,and H2O2 are all"double-edged swords"because they can be extremely toxic to cells at high concentrations.