DNA-Based Catalytic Enantioselective Michael Reactions in Water

摘要

The increasing appreciation of the special properties of water as a reaction medium,combined with the potential advantages of replacing organic solvents by water,have fueled the development of catalytic methodologies for use in water or aqueous media.Despite significant progress in the area of catalytic asymmetric C-C bond-forming reactions in water many challenges remain.For example,a particularly important transformation is the catalytic enantioselective Michael addition reaction,in which an enone substrate undergoes conjugate addition with a carbon nucleophile.