Total Synthesis of the Antibiotic Erypoegin H and Cognates by a PtCl2-Catalyzed Cycloisomerization Reaction

摘要

The growing number of methicillin-resistant Staphylococcus aureus(MRSA)strains that are also resistant to other antibiotics in clinical use,including vancomycin,constitutes a serious threat worldwide.Even though the urgent need for innovative therapeutic agents capable of combating such deadly bacteria has been widely recognized,the number of new lead structures fueling that quest remains alarmingly low.