Dinuclear Ruthenium(II) Triple-Stranded Helicates: Luminescent Supramolecular Cylinders That Bind and Coil DNA and Exhibit Activity against Cancer Cell Lines

摘要

Synthetic agents that bind to DNA and affect its processing are attractive targets in molecular design.Small molecules can regulate specific gene expression and remain at the forefront of clinical application as anticancer and antiviral drugs.Clinical drugs can intercalate (anthracycline antibiotics),minor groove bind (berenil),or form coordination bonds to DNA (cisplatin).