The Constrained Amino Acid β-Acc Confers Potency and Selectivity to Integrin Ligands

摘要

Interactions between the extracellular matrix and membrane proteins are of importance for cell adhesion, tissue formation, and transmembrane signaling processes. Among cell adhesion molecules, integrins occupy a highly prominent position. Many integrins, among them α5β1 and αVβ3, recognize the tripeptide sequence -Arg-Gly-Asp- (RGD) in their ligands. The discovery of the role of the RGD sequence in cell-cell and cell-matrix interactions prompted the development of a broad variety of RGD peptides and peptidomimetics for potential therapeutic applications.