GoId(I)-CataIyzed Synthesis of Functionalized Cyclopentadienes

摘要

The rearrangement of vinyl allene oxides (1,X=O) is a key transformation in the metabolic pathway that converts arachidonic acids into cyclopentenones (3,X=O) [Eq (1)].These rearrangements can proceed by two distinct mechanistic pathways a concerted rearrangement (path a) involving direct addition of the olefin on the epoxide or a stepwise mechanism (path b) through a Nazarov cyclization of an oxypentadienyl cation (2,X=O~-).