Chiral N-Heterocyclic Carbenes in Natural Product Synthesis: Application of Ru-Catalyzed Asymmetric Ring-Opening/Cross-Metathesis and Cu-Catalyzed Allylic Alkylation to Total Synthesis of Baconipyrone C

摘要

Natural product synthesis and development of catalysts and methods benefit from a critical relationship. A new process provides access to alternative, and often more efficient, routes - it renders a previously untenable scheme feasible. Total synthesis, an important testing ground for a new catalyst and the transformation that it promotes, is particularly valuable when it necessitates the discovery of a method that might otherwise remain unknown. Herein, we report an enantioselective synthesis of the unusual siphonariid metabolite baconipyrone C.