alpha,omgega-Functionalized 2,4-Dimethylpentane Dyads and 2,4,6-Trimethylheptane Triads through Asymmetric Hydrogenation

摘要

Chiral analogues of the Crabtree catalysts,[Ir(cod)(py)-(PR3)PF6](that is,[M(N,P)]systems;cod =cycloocta-1,5-diene,py =pyridine)are excellent enantioselective catalysts for hydrogenation reactions of trisubstituted alkenes,and have been used extensively to reduce alkenes that are largely unfunctionalized insofar as they do not contain strongly coordinating groups.Consequently,asymmetric hydroge-nations are potentially possible for a broad range of substrates for which most other chiral catalysts are not effective.