Diastereodivergent Synthesis of Enantiomerically Pure Homoallylic Amine Derivatives Containing Quaternary Carbon Stereocenters

摘要

The design of new methods for the enantioselective construction of all-carbon quaternary stereogenic centers in acyclic systems is still a critical and challenging objective in modern chemistry.Currently,the most-successful methods are asymmetric copper-catalyzed conjugate addition,asymmetric Michael reactions,asymmetric sigmatropic rearrangements,and asymmetric electrophilic and nucleo-philic allylic alkylation.