Total Synthesis of(+)-Azaspiracid-l.Part I:Synthesis of the Fully Elaborated ABCD Aldehyde

摘要

(-)-Azaspiracid-1(2,Figure 1)is a structurally complex marine neurotoxin that is implicated in seafood poisoning.Outbreaks of azaspiracid poisoning were first reported in 1995 and in 1998 the causative toxin was isolated in minute amounts from blue mussels(Mytilus edulis).