Elucidation of Nonstatistical Dynamic Effects in the Cyclization of Enyne Allenes by Means of Kinetic Isotope Effects

摘要

In the first decades following the birth of physical organic chemistry,a set of firm paradigms guided our conception of reactive intermediates,transition states,and reaction coordinates.More recently,the significance of dynamic effects in organic reactions has become increasingly evident through the seminal work conducted by Carpenter,Singleton,Doubleday,Hase,and others.